Facts on Drugs Used in Chemotherapy
Active substance: Streptozocin
Extract from the prescribing information:
"Renal toxicity is dose-related and cumulative and may be severe or fatal. Other major toxicities are nausea and vomiting which may be severe and at times treatment-limiting. In addition, liver dysfunction, diarrhea, and hematological changes have been observed in some patients."
"Streptozocin is mutagenic. When administered parenterally, it has been found to be tumorigenic or carcinogenic in some rodents."
"The physician must judge the possible benefit to the patient against the known toxic effects of this drug in considering the advisability of therapy with ZANOSAR."
The above has been extracted from the Zanosar prescribing information on the Sicor webpages.