Chemo Facts

Facts on Drugs Used in Chemotherapy

Arrow to the left Back to the Homepage

Active substance: Mercaptopurine
Manufacturer: GlaxoSmithKline

Extract from the prescribing information:

"The most consistent, dose-related toxicity is bone marrow suppression. This may be manifest by anemia, leukopenia, thrombocytopenia, or any combination of these. Any of these findings may also reflect progression of the underlying disease."

"Mercaptopurine is hepatotoxic in animals and humans. A small number of deaths have been reported that may have been attributed to hepatic necrosis due to administration of mercaptopurine."

"Mercaptopurine causes chromosomal aberrations in animals and humans and induces dominant-lethal mutations in male mice."

The above has been extracted from the Purinethol prescribing information on the GlaxoSmithKline webpages.