Facts on Drugs Used in Chemotherapy
Active substance: Busulfan
Extract from the prescribing information:
"The most frequent, serious side effect of treatment with busulfan is the induction of bone marrow failure (which may or may not be anatomically hypoplastic) resulting in severe pancytopenia. The pancytopenia caused by busulfan may be more prolonged than that induced with other alkylating agents."
"Malignant tumors and acute leukemias have been reported in patients who have received busulfan therapy, and this drug may be a human carcinogen. The World Health Organization has concluded that there is a causal relationship between busulfan exposure and the development of secondary malignancies."
The above has been extracted from the Myleran prescribing information on the GlaxoSmithKline webpages.