Facts on Drugs Used in Chemotherapy
Active substance: Triethylenethiophosphoramide
Manufacturer: Bedford Laboratories
Extract from the prescribing information:
"Death has occurred after intravesical administration, caused by bone-marrow depression from systematically absorbed drug."
"Death from septicemia and hemorrhage has occurred as a direct result of hematopoietic depression by thiotepa."
"Thiotepa is highly toxic to the hematopoietic system. A rapidly falling white blood cell or platelet count indicates the necessity for discontinuing or reducing the dosage of thiotepa."
"Like many alkylating agents, thiotepa has been reported to be carcinogenic when administered to laboratory animals. Carcinogenicity is shown most clearly in studies using mice, but there is some evidence of carcinogenicity in man. In patients treated with thiotepa, cases of myelodysplastic syndromes and acute non-lymphocytic leukemia have been reported."
The above has been extracted from the Thiotepa prescribing information on the Bedford Laboratories webpages.